UniProt P26718
NKG2-D type II integral membrane protein (P26718)
NKG2-D type II integral membrane protein (UniProt P26718): 16 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P26718
- Protein
- NKG2-D type II integral membrane protein
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 2 · 1 record with a druggable one
Structures
17 records of P26718 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1HYR | Crystal structure of human mica in complex with natural killer cell receptor NKG2D | x-ray diffraction | B, A | — | — |
| 1HYR | Crystal structure of human mica in complex with natural killer cell receptor NKG2D | x-ray diffraction | B, A | — | — |
| 1KCG | NKG2D in complex with ULBP3 | x-ray diffraction | A, B | — | — |
| 1KCG | NKG2D in complex with ULBP3 | x-ray diffraction | A, B | — | — |
| 1MPU | Crystal Structure of the free human NKG2D immunoreceptor | x-ray diffraction | A | — | — |
| 1MPU | Crystal structure of the free human NKG2D immunoreceptor | x-ray diffraction | A | — | — |
| 4PDC | Crystal structure of Cowpox virus CPXV018 (OMCP) bound to human NKG2D | x-ray diffraction | A, B, C, D | — | — |
| 4PDC | Crystal structure of cowpox virus CPXV018 (omcp) bound to human NKG2D | x-ray diffraction | A, B, C, D | — | — |
| 4S0U | Crystal structure of NKG2D in complex with ULBP6 | x-ray diffraction | A, B | — | — |
| 4S0U | Crystal structure of NKG2D in complex with ULBP6 | x-ray diffraction | A, B | — | — |
| 7FI5 | Crystal structure of human mica mutants in complex with natural killer cell receptor NKG2D | x-ray diffraction | A, B | — | — |
| 7FI6 | Crystal structure of human mica mutants in complex with natural killer cell receptor NKG2D | x-ray diffraction | A, B | — | — |
| 7FI7 | Crystal structure of human mica mutants in complex with natural killer cell receptor NKG2D | x-ray diffraction | A, B | — | — |
| 7FI8 | Crystal structure of human mica mutants in complex with natural killer cell receptor NKG2D | x-ray diffraction | A, B | — | — |
| 7FI9 | Crystal structure of human mica mutants in complex with natural killer cell receptor NKG2D | x-ray diffraction | A, B | — | — |
| 8SE5 | NKG2D complexed with inhibitor 14 | x-ray diffraction | B, A | ZW7 | 1 (best 0.75) |
| P26718 | AlphaFold monomer V2.0 prediction for NKG2-D type II integral membrane protein (P26718) | predicted | A | — | 1 (best 0.28) |
Ligands
- ZW7 · N-{(1S)-2-[(1R,5S,6S)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide · in 1 record
Experiment against prediction
- 4PDC chain B against the predicted model P26718: TM-score 0.99, RMSD 0.49 Å
- 4PDC chain B against the predicted model P26718: TM-score 0.99, RMSD 0.49 Å
- 4PDC chain A against the predicted model P26718: TM-score 0.99, RMSD 0.52 Å
- 4PDC chain A against the predicted model P26718: TM-score 0.99, RMSD 0.52 Å
- 1KCG chain B against the predicted model P26718: TM-score 0.98, RMSD 0.55 Å
- 1KCG chain B against the predicted model P26718: TM-score 0.98, RMSD 0.55 Å
- 7FI8 chain A against the predicted model P26718: TM-score 0.98, RMSD 0.67 Å
- 7FI6 chain A against the predicted model P26718: TM-score 0.98, RMSD 0.67 Å
- 1HYR chain A against the predicted model P26718: TM-score 0.98, RMSD 0.69 Å
- 1HYR chain A against the predicted model P26718: TM-score 0.98, RMSD 0.69 Å
Elsewhere
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