MolNFT v1 · #149586 · protein

The crystal structure of uninhibited C183S/C217S mutant of human ca VII

6G4T · Carbonic anhydrase 7: “The crystal structure of uninhibited C183S/C217S mutant of human ca VII”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.55). MolNFT v1 #149586 on GenesisL1: 3D structure, binding sites and…

PDB: 6G4T
Type: protein
Length: 259 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Carbonic anhydrase 7
EC: 4.2.1.1
UniProt: P43166
Ligands: ZN
Pockets: 1 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 14% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Carbonic anhydrase 7 (EC 4.2.1.1)	protein	259	14% helix, 31% strand	P43166

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	141	0.55	0.81	23	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

6G4T · The crystal structure of uninhibited C183S/C217S mutant of human CA VII · the same entry in another collection · chain A against A, TM-score 1.00
P43166 · AlphaFold monomer V2.0 prediction for carbonic anhydrase 7 (P43166) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43166
Elsewhere: RCSB PDB 6G4T · PDBe 6G4T · UniProt P43166

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