MolNFT v1 · #149549 · protein
Structure of tellurium-centred anderson-evans polyoxotungstate (tew) bound to the nucleotide binding domain of HSP70. second structure of two tew-HSP70 structures deposited.
6G3S · Heat shock 70 kda protein 1A: “Structure of tellurium-centred anderson-evans polyoxotungstate (tew) bound to the nucleotide binding domain…”. X-ray diffraction, 5 ligands (TEW, ADP, NA), 1 pocket (best druggability 0.75). MolNFT v1…
- PDB
- 6G3S
- Type
- protein
- Length
- 379 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock 70 kda protein 1A
- UniProt
- P0DMV8
- Ligands
- TEW, ADP, NA, MG, PO4
- Pockets
- 1 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock 70 kda protein 1A | protein | 379 | 41% helix, 29% strand | P0DMV8 |
Ligands and binding sites
- TEW · 6-tungstotellurate(VI) · ligand · 2 copies · chains A
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- NA · Sodium ion · metal · 3 copies · chains A
- MG · Magnesium ion · metal · chains A
- PO4 · Phosphate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 672 | 0.75 | 0.81 | 67 | ADP, MG, PO4, NA |
Compared structures
- 6G3S · Structure of tellurium-centred Anderson-Evans polyoxotungstate (TEW) bound to the… · the same entry in another collection · chain A against A, TM-score 1.00
- P0DMV8 · AlphaFold monomer V2.0 prediction for heat shock 70 kda protein 1A (P0DMV8) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0DMV8
- Elsewhere: RCSB PDB 6G3S · PDBe 6G3S · UniProt P0DMV8
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