MolNFT v1 · #149514 · protein
Human cardiac myosin binding protein C C1 ig-domain bound to native cardiac thin filament
6G2T · Actin, cytoplasmic 2: “Human cardiac myosin binding protein C C1 ig-domain bound to native cardiac thin filament”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #149514 on GenesisL1: 3D structure, binding sites…
- PDB
- 6G2T
- Type
- protein
- Length
- 3,384 residues
- Chains
- 16
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin, cytoplasmic 2; Myosin-binding protein C, cardiac-type; Tropomyosin
- UniProt
- P63261, Q14896
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 3 distinct chains · 46% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Actin, cytoplasmic 2 | protein | 370 | 42% helix, 20% strand | P63261 |
| G, H, I, J, K, L | Myosin-binding protein C, cardiac-type | protein | 104 | 7% helix, 56% strand | Q14896 |
| M, N, O, P | Tropomyosin | protein | 135 | 86% helix, 0% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 192 | 0.81 | 0.96 | 40 | empty |
| 2 | 185 | 0.80 | 0.95 | 39 | empty |
| 3 | 894 | 0.80 | 0.82 | 64 | empty |
| 4 | 182 | 0.80 | 0.95 | 41 | empty |
| 5 | 179 | 0.80 | 0.95 | 41 | empty |
Interfaces
40 interfaces between chains.
- M–N · 1619 Ų buried · 0 hydrogen bonds · protein-protein
- O–P · 1618 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 1223 Ų buried · 10 hydrogen bonds · protein-protein
- C–E · 1223 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 1207 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6G2T · human cardiac myosin binding protein C C1 Ig-domain bound to native cardiac thin filament · the same entry in another collection · chain P against P, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63261
- Every structure of UniProt Q14896
- Elsewhere: RCSB PDB 6G2T · PDBe 6G2T · UniProt P63261 · UniProt Q14896
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