MolNFT v1 · #149447 · protein
Crystal structure of the first bromodomain of human BRD4 in complex with an acetylated SIRT7 peptide (K272AC/K275AC)
6G0S: “Crystal structure of the first bromodomain of human BRD4 in complex with an acetylated SIRT7 peptide…”. X-ray diffraction. MolNFT v1 #149447 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6G0S
- Type
- protein
- Length
- 262 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O60885, Q9NRC8
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 127 | — | O60885 |
| D | — | protein | 10 | — | Q9NRC8 |
| B | — | protein | 125 | — | O60885 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6G0S · Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated… · the same entry in another collection · chain A against A, TM-score 1.00
- O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9NRC8 · AlphaFold monomer V2.0 prediction for NAD-dependent protein deacetylase sirtuin-7 (Q9NRC8) · a predicted model of the same protein · chain D against A, TM-score 0.65
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60885
- Every structure of UniProt Q9NRC8
- Elsewhere: RCSB PDB 6G0S · PDBe 6G0S · UniProt O60885 · UniProt Q9NRC8
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