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Crystal structure of the first bromodomain of human BRD4 in complex with an acetylated SIRT7 peptide (K272AC/K275AC)

Analyse Crystal structure of the first bromodomain of human BRD4 in complex with an… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6G0S
Type: protein
Length: 262 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O60885, Q9NRC8

Structure

x-ray diffraction · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	127	—	O60885
D	—	protein	10	—	Q9NRC8
B	—	protein	125	—	O60885

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6G0S · Crystal Structure of the first bromodomain of human BRD4 in complex with an acetylated… · the same entry in another collection · chain A against A, TM-score 1.00
O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.98
Q9NRC8 · AlphaFold monomer V2.0 prediction for NAD-dependent protein deacetylase sirtuin-7 (Q9NRC8) · a predicted model of the same protein · chain D against A, TM-score 0.65

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O60885
Every structure of UniProt Q9NRC8
Elsewhere: RCSB PDB 6G0S · PDBe 6G0S · UniProt O60885 · UniProt Q9NRC8

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