MolNFT v1 · #149315 · protein

Chimeric titin Z1Z2-Z1Z2 tandem (Z1212) functionalized with a grgds exogenous peptide from fibronectin

6FWX · TITIN,TITIN,TITIN: “Chimeric titin Z1Z2-Z1Z2 tandem (Z1212) functionalized with a grgds exogenous peptide from fibronectin”. X-ray diffraction, 1 pocket (best druggability 0.72). MolNFT v1 #149315 on GenesisL1: 3D structure, binding…

PDB: 6FWX
Type: protein
Length: 390 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TITIN,TITIN,TITIN
EC: 2.7.11.1
UniProt: Q8WZ42
Pockets: 1 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 2% helix, 60% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TITIN,TITIN,TITIN (EC 2.7.11.1)	protein	195	3% helix, 59% strand	Q8WZ42
B	TITIN,TITIN,TITIN (EC 2.7.11.1)	protein	195	2% helix, 61% strand	Q8WZ42

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.72	0.97	17	empty

Interfaces

1 interface between chains.

A–B · 582 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

6FWX · Chimeric titin Z1Z2-Z1Z2 tandem (Z1212) functionalized with a GRGDS exogenous peptide… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WZ42
Elsewhere: RCSB PDB 6FWX · PDBe 6FWX · UniProt Q8WZ42

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