MolNFT v1 · #149167 · protein

Influenza B/MEMPHIS/13/03 endonuclease with I38T mutation with bound inhibitor, baloxavir acid (bxa)

6FS9 · Polymerase acidic protein: “Influenza B/MEMPHIS/13/03 endonuclease with I38T mutation with bound inhibitor, baloxavir acid (bxa)”. X-ray diffraction, 3 ligands (E4Z, MN, CL), 1 pocket (best druggability 0.56). MolNFT v1 #149167 on…

PDB: 6FS9
Type: protein
Length: 183 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polymerase acidic protein
EC: 3.1.-.-
UniProt: Q5V8Z9
Ligands: E4Z, MN, CL
Pockets: 1 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polymerase acidic protein (EC 3.1.-.-)	protein	183	49% helix, 16% strand	Q5V8Z9

Ligands and binding sites

E4Z · Baloxavir acid · ligand · chains A
MN · Manganese (II) ion · metal · 2 copies · chains A
CL · Chloride ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	290	0.56	0.76	34	MN, E4Z, CL

Compared structures

6FS9 · Influenza B/Memphis/13/03 endonuclease with I38T mutation with bound inhibitor, baloxavir… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5V8Z9
Elsewhere: RCSB PDB 6FS9 · PDBe 6FS9 · UniProt Q5V8Z9

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