MolNFT v1 · #149045 · protein
X-ray structure of homo sapiens fumarylacetoacetate hydrolase domain containing protein 1 (FAHD1) at 1.56A resolution.
6FOH · Acylpyruvase FAHD1, mitochondrial: “X-ray structure of homo sapiens fumarylacetoacetate hydrolase domain containing protein 1 (FAHD1) at 1.56A…”. X-ray diffraction, 2 ligands (MG, CL), 9 pockets (best druggability 0.48). MolNFT v1…
- PDB
- 6FOH
- Type
- protein
- Length
- 430 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acylpyruvase FAHD1, mitochondrial
- EC
- 3.7.1.5, 4.1.1.3
- UniProt
- Q6P587
- Ligands
- MG, CL
- Pockets
- 9 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5, 4.1.1.3) | protein | 213 | 24% helix, 36% strand | Q6P587 |
| B | Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5, 4.1.1.3) | protein | 217 | 25% helix, 35% strand | Q6P587 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.48 | 0.81 | 17 | empty |
| 2 | 140 | 0.43 | 0.76 | 28 | empty |
| 3 | 64 | 0.42 | 0.81 | 16 | empty |
| 4 | 89 | 0.42 | 0.78 | 15 | empty |
| 5 | 82 | 0.41 | 0.79 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1438 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 6FOH · X-ray structure of homo sapiens Fumarylacetoacetate hydrolase domain containing protein 1… · the same entry in another collection · chain A against A, TM-score 1.00
- Q6P587 · AlphaFold monomer V2.0 prediction for acylpyruvase FAHD1, mitochondrial (Q6P587) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P587
- Elsewhere: RCSB PDB 6FOH · PDBe 6FOH · UniProt Q6P587
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.