MolNFT v1 · #149038 · protein
Human xylosyltransferase 1 apo structure
6FOA: “Human xylosyltransferase 1 apo structure”. X-ray diffraction, 3 ligands (NAG, NA, PO4), 6 pockets (best druggability 0.75). MolNFT v1 #149038 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6FOA
- Type
- protein
- Length
- 699 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Xylosyltransferase 1
- EC
- 2.4.2.26
- UniProt
- Q86Y38
- Ligands
- NAG, NA, PO4
- Pockets
- 6 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Xylosyltransferase 1 (EC 2.4.2.26) | protein | 699 | 30% helix, 25% strand | Q86Y38 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
- NA · Sodium ion · metal · chains A
- PO4 · Phosphate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1054 | 0.75 | 0.78 | 89 | PO4 |
| 2 | 477 | 0.67 | 0.78 | 49 | empty |
| 3 | 156 | 0.43 | 0.75 | 27 | empty |
| 4 | 102 | 0.43 | 0.78 | 20 | empty |
| 5 | 67 | 0.36 | 0.78 | 17 | empty |
Modifications
Observed in the structure: 6 disulfide, 1 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86Y38
- Elsewhere: RCSB PDB 6FOA · PDBe 6FOA · UniProt Q86Y38
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