MolNFT v1 · #148962 · protein
Carp domain of mouse cyclase-associated protein 1 (CAP1) bound to ADP- actin
6FM2 · Actin, alpha skeletal muscle: “Carp domain of mouse cyclase-associated protein 1 (CAP1) bound to ADP- actin”. X-ray diffraction, 2 ligands (ADP, MG), 2 pockets (best druggability 0.76). MolNFT v1 #148962 on GenesisL1: 3D structure…
- PDB
- 6FM2
- Type
- protein
- Length
- 528 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin, alpha skeletal muscle; Adenylyl cyclase-associated protein 1
- UniProt
- P68135, P40124
- Ligands
- ADP, MG
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Actin, alpha skeletal muscle | protein | 371 | 43% helix, 19% strand | P68135 |
| B | Adenylyl cyclase-associated protein 1 | protein | 157 | 2% helix, 58% strand | P40124 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 566 | 0.76 | 0.82 | 58 | empty |
| 2 | 403 | 0.73 | 0.84 | 54 | MG, ADP |
Interfaces
1 interface between chains.
- A–B · 991 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (methylation).
Compared structures
- 6FM2 · CARP domain of mouse cyclase-associated protein 1 (CAP1) bound to ADP-actin · the same entry in another collection · chain A against A, TM-score 1.00
- P40124 · AlphaFold monomer V2.0 prediction for adenylyl cyclase-associated protein 1 (P40124) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P68135 · AlphaFold monomer V2.0 prediction for actin, alpha skeletal muscle (P68135) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68135
- Every structure of UniProt P40124
- Elsewhere: RCSB PDB 6FM2 · PDBe 6FM2 · UniProt P68135 · UniProt P40124
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