MolNFT v1 · #148856 · protein
Crystal structure of cng mimicking nak-eapp mutant (T67A) cocrystallized with K+
6FIZ · Potassium channel PROTEIN,CYCLIC nucleotide-gated olfactory…: “Crystal structure of cng mimicking nak-eapp mutant (T67A) cocrystallized with K+”. X-ray diffraction, 2 ligands (GLY, K), 20 pockets (best druggability 0.76). MolNFT v1…
- PDB
- 6FIZ
- Type
- protein
- Length
- 1,462 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium channel PROTEIN,CYCLIC nucleotide-gated olfactory CHANNEL,POTASSIUM channel…
- UniProt
- Q81HW2, Q16280
- Ligands
- GLY, K
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, J, K, L, N, O, P | Potassium channel PROTEIN,CYCLIC nucleotide-gated olfactory CHANNEL,POTASSIUM channel protein | protein | 91 | 79% helix, 0% strand | Q81HW2, Q16280 |
| I, M | Potassium channel PROTEIN,CYCLIC nucleotide-gated olfactory CHANNEL,POTASSIUM channel protein | protein | 94 | 80% helix, 0% strand | Q81HW2, Q16280 |
Ligands and binding sites
- GLY · Glycine · ligand · 60 copies · chains A, B, C, J, N, D, E, F, H, G, I, L, K, M, P, O
- K · Potassium ion · metal · 12 copies · chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
- MPD · (4S)-2-methyl-2,4-pentanediol · additive · 7 copies · chains D, F, K, G, H, J, I, M, N, O
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 793 | 0.76 | 0.80 | 97 | MPD |
| 2 | 703 | 0.76 | 0.81 | 75 | GLY |
| 3 | 497 | 0.67 | 0.78 | 55 | empty |
| 4 | 333 | 0.65 | 0.80 | 47 | GLY |
| 5 | 251 | 0.62 | 0.80 | 35 | GLY |
Interfaces
33 interfaces between chains.
- B–C · 889 Ų buried · 8 hydrogen bonds · protein-protein
- E–H · 888 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 885 Ų buried · 9 hydrogen bonds · protein-protein
- F–G · 881 Ų buried · 11 hydrogen bonds · protein-protein
- G–H · 879 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6FIZ · Crystal Structure of CNG mimicking NaK-EAPP mutant (T67A) cocrystallized with K+ · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q81HW2
- Every structure of UniProt Q16280
- Elsewhere: RCSB PDB 6FIZ · PDBe 6FIZ · UniProt Q81HW2 · UniProt Q16280
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