Crystal structure of BAZ2A phd zinc finger in complex with fr 19

Structure

x-ray diffraction · 3 distinct chains · 15% helix, 15% strand (DSSP).

Ligands and binding sites

• DEW · 2-azanyl-1-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-yl)ethanone · ligand · 2 copies · chains B, C
• ZN · Zinc ion · metal · 8 copies · chains A, B, C, D
• K · Potassium ion · metal · 2 copies · chains A, D, C
• PO4 · Phosphate ion · ion · 4 copies · chains A, B, C, D
• GOL · Glycerol · additive · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

6 interfaces between chains.

• A–C · 732 Ų buried · 10 hydrogen bonds · protein-protein
• B–D · 718 Ų buried · 9 hydrogen bonds · protein-protein
• A–D · 419 Ų buried · 7 hydrogen bonds · protein-protein
• C–D · 77 Ų buried · 1 hydrogen bond · protein-protein
• A–B · 73 Ų buried · 0 hydrogen bonds · protein-protein

Compared structures

• 6FI0 · Crystal structure of BAZ2A PHD zinc finger in complex with Fr 19 · the same entry in another collection · chain D against D, TM-score 1.00
• Q9UIF9 · AlphaFold monomer V2.0 prediction for bromodomain adjacent to zinc finger domain protein… · a predicted model of the same protein · chain C against A, TM-score 0.88

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9UIF9
• Elsewhere: RCSB PDB 6FI0 · PDBe 6FI0 · UniProt Q9UIF9