MolNFT v1 · #148816 · protein
Crystal structure of BAZ2A phd zinc finger in complex with H3 3-mer peptide
6FHU · Bromodomain adjacent to zinc finger domain protein 2A: “Crystal structure of BAZ2A phd zinc finger in complex with H3 3-mer peptide”. X-ray diffraction, 2 ligands (ZN, PO4), 4 pockets (best druggability 0.60). MolNFT v1 #148816 on…
- PDB
- 6FHU
- Type
- protein
- Length
- 217 residues
- Chains
- 7
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bromodomain adjacent to zinc finger domain protein 2A; Ala-arg-tam
- UniProt
- Q9UIF9
- Ligands
- ZN, PO4
- Pockets
- 4 · best druggability 0.60
Structure
x-ray diffraction · 5 distinct chains · 15% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bromodomain adjacent to zinc finger domain protein 2A | protein | 52 | 19% helix, 15% strand | Q9UIF9 |
| B | Bromodomain adjacent to zinc finger domain protein 2A | protein | 51 | 14% helix, 16% strand | Q9UIF9 |
| C | Bromodomain adjacent to zinc finger domain protein 2A | protein | 52 | 13% helix, 15% strand | Q9UIF9 |
| D | Bromodomain adjacent to zinc finger domain protein 2A | protein | 53 | 13% helix, 15% strand | Q9UIF9 |
| F, H, G | Ala-arg-tam | protein | 3 | 0% helix, 33% strand | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 8 copies · chains A, B, C, D
- PO4 · Phosphate ion · ion · 3 copies · chains A, B, D
- GOL · Glycerol · additive · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 89 | 0.60 | 0.88 | 21 | empty |
| 2 | 127 | 0.58 | 0.84 | 21 | empty |
| 3 | 109 | 0.57 | 0.84 | 24 | empty |
| 4 | 63 | 0.36 | 0.78 | 21 | empty |
Interfaces
9 interfaces between chains.
- A–C · 728 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 658 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 402 Ų buried · 4 hydrogen bonds · protein-protein
- B–H · 269 Ų buried · 5 hydrogen bonds · protein-protein
- A–F · 267 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (nonstandard).
Compared structures
- 6FHU · Crystal structure of BAZ2A PHD zinc finger in complex with H3 3-mer peptide · the same entry in another collection · chain G against G, TM-score 1.00
- Q9UIF9 · AlphaFold monomer V2.0 prediction for bromodomain adjacent to zinc finger domain protein… · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UIF9
- Elsewhere: RCSB PDB 6FHU · PDBe 6FHU · UniProt Q9UIF9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.