MolNFT v1 · #148764 · protein
Human fcrn extra-cellular domain complexed with Fab fragment of rozanolixizumab
6FGB · IgG receptor fcrn large subunit P51: “Human fcrn extra-cellular domain complexed with Fab fragment of rozanolixizumab”. X-ray diffraction, 2 ligands (NA, CL), 10 pockets (best druggability 0.70). MolNFT v1 #148764 on GenesisL1: 3D…
- PDB
- 6FGB
- Type
- protein
- Length
- 800 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IgG receptor fcrn large subunit P51; Beta-2-microglobulin; 1519.G57- light chain…
- UniProt
- P55899, P61769
- Ligands
- NA, CL
- Pockets
- 10 · best druggability 0.70
Structure
x-ray diffraction · 4 distinct chains · 12% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | IgG receptor fcrn large subunit P51 | protein | 265 | 25% helix, 42% strand | P55899 |
| B | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | P61769 |
| L | 1519.G57- light chain | protein | 219 | 6% helix, 52% strand | — |
| H | 1519.G57- heavy chain | protein | 217 | 7% helix, 47% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 620 | 0.70 | 0.78 | 62 | empty |
| 2 | 337 | 0.63 | 0.79 | 46 | NA |
| 3 | 158 | 0.49 | 0.78 | 27 | empty |
| 4 | 55 | 0.48 | 0.86 | 21 | empty |
| 5 | 236 | 0.48 | 0.74 | 32 | empty |
Interfaces
6 interfaces between chains.
- L–H · 1781 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1396 Ų buried · 25 hydrogen bonds · protein-protein
- A–H · 698 Ų buried · 14 hydrogen bonds · protein-protein
- A–L · 311 Ų buried · 5 hydrogen bonds · protein-protein
- B–H · 78 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 6FGB · Human FcRn extra-cellular domain complexed with Fab fragment of Rozanolixizumab · the same entry in another collection · chain A against A, TM-score 1.00
- P55899 · AlphaFold monomer V2.0 prediction for IgG receptor fcrn large subunit P51 (P55899) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55899
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 6FGB · PDBe 6FGB · UniProt P55899 · UniProt P61769
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