MolNFT v1 · #148728 · protein
Crystal structure of uncomplexed RAB32 in the active GTP-bound state at 2.13 ångström resolution
6FF8 · RAS-related protein rab-32: “Crystal structure of uncomplexed RAB32 in the active GTP-bound state at 2.13 ångström resolution”. X-ray diffraction, 2 ligands (GTP, MG), 2 pockets (best druggability 0.74). MolNFT v1 #148728 on…
- PDB
- 6FF8
- Type
- protein
- Length
- 345 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS-related protein rab-32
- UniProt
- Q13637
- Ligands
- GTP, MG
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS-related protein rab-32 | protein | 175 | 37% helix, 31% strand | Q13637 |
| B | RAS-related protein rab-32 | protein | 170 | 35% helix, 31% strand | Q13637 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 829 | 0.74 | 0.78 | 78 | GTP, MG |
| 2 | 288 | 0.59 | 0.78 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 625 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6FF8 · Crystal structure of uncomplexed Rab32 in the active GTP-bound state at 2.13 Angstrom… · the same entry in another collection · chain A against A, TM-score 1.00
- Q13637 · AlphaFold monomer V2.0 prediction for RAS-related protein rab-32 (Q13637) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13637
- Elsewhere: RCSB PDB 6FF8 · PDBe 6FF8 · UniProt Q13637
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.