MolNFT v1 · #148710 · protein

Structure of 14-3-3 gamma in complex with CAMKK2 14-3-3 binding motif SER511

6FEL · 14-3-3 protein gamma: “Structure of 14-3-3 gamma in complex with CAMKK2 14-3-3 binding motif SER511”. X-ray diffraction, 9 pockets (best druggability 0.72). MolNFT v1 #148710 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6FEL
Type: protein
Length: 927 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 14-3-3 protein gamma; CALCIUM/CALMODULIN-dependent protein kinase kinase 2
EC: 2.7.11.17
UniProt: P61981, Q96RR4
Pockets: 9 · best druggability 0.72

Structure

x-ray diffraction · 6 distinct chains · 81% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	14-3-3 protein gamma	protein	229	83% helix, 0% strand	P61981
C	14-3-3 protein gamma	protein	225	81% helix, 0% strand	P61981
B	14-3-3 protein gamma	protein	220	82% helix, 0% strand	P61981
D	14-3-3 protein gamma	protein	228	83% helix, 0% strand	P61981
E, F, H	CALCIUM/CALMODULIN-dependent protein kinase kinase 2 (EC 2.7.11.17)	protein	6	0% helix, 0% strand	Q96RR4
G	CALCIUM/CALMODULIN-dependent protein kinase kinase 2 (EC 2.7.11.17)	protein	7	0% helix, 0% strand	Q96RR4

Pockets

9 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	578	0.72	0.80	58	empty
2	594	0.69	0.78	54	empty
3	555	0.65	0.76	57	empty
4	460	0.65	0.78	44	empty
5	214	0.57	0.80	27	empty

Interfaces

11 interfaces between chains.

C–D · 1160 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 1095 Å² buried · 13 hydrogen bonds · protein-protein
A–C · 732 Å² buried · 4 hydrogen bonds · protein-protein
C–G · 517 Å² buried · 16 hydrogen bonds · protein-protein
A–E · 473 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (phosphorylation).

Compared structures

6FEL · Structure of 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser511 · the same entry in another collection · chain H against H, TM-score 1.00
P61981 · AlphaFold monomer V2.0 prediction for 14-3-3 protein gamma (P61981) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61981
Every structure of UniProt Q96RR4
Elsewhere: RCSB PDB 6FEL · PDBe 6FEL · UniProt P61981 · UniProt Q96RR4

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