MolNFT v1 · #148646 · protein
Structural and functional characterisation of frataxin (fxn) like protein from chaetomium thermophilum
6FCO · Mitochondrial frataxin-like protein: “Structural and functional characterisation of frataxin (fxn) like protein from chaetomium thermophilum”. X-ray diffraction, 6 pockets (best druggability 0.88). MolNFT v1 #148646 on GenesisL1: 3D…
- PDB
- 6FCO
- Type
- protein
- Length
- 684 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial frataxin-like protein
- UniProt
- G0S1Z8
- Pockets
- 6 · best druggability 0.88
Structure
x-ray diffraction · 5 distinct chains · 32% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitochondrial frataxin-like protein | protein | 119 | 31% helix, 35% strand | G0S1Z8 |
| B | Mitochondrial frataxin-like protein | protein | 118 | 31% helix, 31% strand | G0S1Z8 |
| C | Mitochondrial frataxin-like protein | protein | 121 | 31% helix, 35% strand | G0S1Z8 |
| D | Mitochondrial frataxin-like protein | protein | 112 | 33% helix, 33% strand | G0S1Z8 |
| E, F | Mitochondrial frataxin-like protein | protein | 107 | 35% helix, 35% strand | G0S1Z8 |
Ligands and binding sites
- MLA · Malonic acid · additive · 4 copies · chains A, D, E, C, F, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 923 | 0.88 | 0.90 | 104 | MLA |
| 2 | 161 | 0.69 | 0.88 | 29 | empty |
| 3 | 183 | 0.63 | 0.84 | 32 | empty |
| 4 | 160 | 0.58 | 0.82 | 32 | empty |
| 5 | 66 | 0.38 | 0.78 | 20 | empty |
Interfaces
12 interfaces between chains.
- E–F · 842 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 819 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 766 Ų buried · 4 hydrogen bonds · protein-protein
- C–F · 453 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 392 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6FCO · Structural and functional characterisation of Frataxin (FXN) like protein from Chaetomium… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0S1Z8
- Elsewhere: RCSB PDB 6FCO · PDBe 6FCO · UniProt G0S1Z8
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