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Structural and functional characterisation of frataxin (fxn) like protein from chaetomium thermophilum

Analyse Structural and functional characterisation of frataxin (fxn) like protein from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6FCO
Type: protein
Length: 684 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitochondrial frataxin-like protein
UniProt: G0S1Z8
Pockets: 6 · best druggability 0.88

Structure

x-ray diffraction · 5 distinct chains · 32% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitochondrial frataxin-like protein	protein	119	31% helix, 35% strand	G0S1Z8
B	Mitochondrial frataxin-like protein	protein	118	31% helix, 31% strand	G0S1Z8
C	Mitochondrial frataxin-like protein	protein	121	31% helix, 35% strand	G0S1Z8
D	Mitochondrial frataxin-like protein	protein	112	33% helix, 33% strand	G0S1Z8
E, F	Mitochondrial frataxin-like protein	protein	107	35% helix, 35% strand	G0S1Z8

Ligands and binding sites

MLA · Malonic acid · additive · 4 copies · chains A, D, E, C, F, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	923	0.88	0.90	104	MLA
2	161	0.69	0.88	29	empty
3	183	0.63	0.84	32	empty
4	160	0.58	0.82	32	empty
5	66	0.38	0.78	20	empty

Interfaces

12 interfaces between chains.

E–F · 842 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 819 Å² buried · 4 hydrogen bonds · protein-protein
A–D · 766 Å² buried · 4 hydrogen bonds · protein-protein
C–F · 453 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 392 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

6FCO · Structural and functional characterisation of Frataxin (FXN) like protein from Chaetomium… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0S1Z8
Elsewhere: RCSB PDB 6FCO · PDBe 6FCO · UniProt G0S1Z8

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