MolNFT v1 · #148645 · protein
Crystal structure of human PCNA soaked with P47PHOX(106-127) peptide
6FCN · Proliferating cell nuclear antigen: “Crystal structure of human PCNA soaked with P47PHOX(106-127) peptide”. X-ray diffraction, 5 pockets (best druggability 0.45). MolNFT v1 #148645 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6FCN
- Type
- protein
- Length
- 755 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proliferating cell nuclear antigen
- UniProt
- P12004
- Pockets
- 5 · best druggability 0.45
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Proliferating cell nuclear antigen | protein | 252 | 20% helix, 45% strand | P12004 |
| C | Proliferating cell nuclear antigen | protein | 252 | 20% helix, 44% strand | P12004 |
| E | Proliferating cell nuclear antigen | protein | 251 | 20% helix, 44% strand | P12004 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 122 | 0.45 | 0.77 | 18 | empty |
| 2 | 82 | 0.39 | 0.78 | 18 | empty |
| 3 | 81 | 0.36 | 0.76 | 22 | empty |
| 4 | 80 | 0.36 | 0.76 | 18 | empty |
| 5 | 64 | 0.32 | 0.75 | 17 | empty |
Interfaces
3 interfaces between chains.
- C–E · 753 Ų buried · 11 hydrogen bonds · protein-protein
- A–E · 752 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 748 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 6FCN · Crystal structure of human PCNA soaked with p47phox(106-127) peptide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12004
- Elsewhere: RCSB PDB 6FCN · PDBe 6FCN · UniProt P12004
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