MolNFT v1 · #148621 · protein
Crystal structure of the EIF4E-EIF4G complex from chaetomium thermophilum in the cap-bound state
6FBZ · Eukaryotic translation initiation factor 4E-like protein…: “Crystal structure of the EIF4E-EIF4G complex from chaetomium thermophilum in the cap-bound state”. X-ray diffraction, 1 ligand (MGP), 2 pockets (best druggability 0.44).…
- PDB
- 6FBZ
- Type
- protein
- Length
- 269 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E-like protein, eukaryotic translation…
- UniProt
- G0SCU4, G0SFP0
- Ligands
- MGP
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 24% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4E-like protein, eukaryotic translation initiation factor 4E-like protein | protein | 191 | 20% helix, 29% strand | G0SCU4 |
| B | Eukaryotic translation initiation factor 4G | protein | 78 | 33% helix, 3% strand | G0SFP0 |
Ligands and binding sites
- MGP · 7-methyl-guanosine-5'-triphosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 134 | 0.44 | 0.76 | 20 | empty |
| 2 | 67 | 0.40 | 0.79 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 2151 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 6FBZ · Crystal structure of the eIF4E-eIF4G complex from Chaetomium thermophilum in the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SCU4
- Every structure of UniProt G0SFP0
- Elsewhere: RCSB PDB 6FBZ · PDBe 6FBZ · UniProt G0SCU4 · UniProt G0SFP0
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