MolNFT v1 · #148069 · protein

Crystal structure of the filamin a ig-like domains 3-5 mutant P637Q

6EW1 · Filamin-a: “Crystal structure of the filamin a ig-like domains 3-5 mutant P637Q”. X-ray diffraction, 4 pockets (best druggability 0.46). MolNFT v1 #148069 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6EW1
Type: protein
Length: 288 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Filamin-a
UniProt: P21333
Pockets: 4 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 4% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Filamin-a	protein	288	4% helix, 46% strand	P21333

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	130	0.46	0.78	22	empty
2	98	0.41	0.77	22	empty
3	73	0.39	0.78	22	empty
4	82	0.29	0.72	18	empty

Compared structures

6EW1 · Crystal structure of the Filamin A Ig-like domains 3-5 mutant P637Q · the same entry in another collection · chain A against A, TM-score 1.00
P21333 · AlphaFold monomer V2.0 prediction for filamin-a (P21333) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21333
Elsewhere: RCSB PDB 6EW1 · PDBe 6EW1 · UniProt P21333

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