MolNFT v1 · #147938 · protein
Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins
6ES7 · Nuclear receptor coactivator 3: “Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins”. Solution nmr, 1 pocket (best druggability 0.77). MolNFT v1 #147938 on GenesisL1: 3D structure…
- PDB
- 6ES7
- Type
- protein
- Length
- 94 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear receptor coactivator 3; Creb-binding protein
- EC
- 2.3.1.48
- UniProt
- Q9Y6Q9, Q92793
- Pockets
- 1 · best druggability 0.77
Structure
solution nmr · 2 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear receptor coactivator 3 (EC 2.3.1.48) | protein | 44 | 64% helix, 0% strand | Q9Y6Q9 |
| B | Creb-binding protein (EC 2.3.1.48) | protein | 50 | 74% helix, 0% strand | Q92793 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 127 | 0.77 | 0.95 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1557 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 6ES7 · Structure and dynamics conspire in the evolution of affinity between intrinsically… · the same entry in another collection · chain A against A, TM-score 1.00
- Q92793 · AlphaFold monomer V2.0 prediction for creb-binding protein (Q92793) · a predicted model of the same protein · chain B against A, TM-score 0.55
- Q9Y6Q9 · AlphaFold monomer V2.0 prediction for nuclear receptor coactivator 3 (Q9Y6Q9) · a predicted model of the same protein · chain A against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y6Q9
- Every structure of UniProt Q92793
- Elsewhere: RCSB PDB 6ES7 · PDBe 6ES7 · UniProt Q9Y6Q9 · UniProt Q92793
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