MolNFT v1 · #14782 · protein
Disulfide deficient mutant of vascular endothelial growth factor a (C61A and C104A)
1MKK: “Disulfide deficient mutant of vascular endothelial growth factor a (C61A and C104A)”. X-ray diffraction, 2 pockets (best druggability 0.50). MolNFT v1 #14782 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1MKK
- Type
- protein
- Length
- 187 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vascular endothelial growth factor a
- UniProt
- P15692
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 14% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vascular endothelial growth factor a | protein | 93 | 16% helix, 57% strand | P15692 |
| B | Vascular endothelial growth factor a | protein | 94 | 13% helix, 57% strand | P15692 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 163 | 0.50 | 0.78 | 20 | empty |
| 2 | 177 | 0.48 | 0.76 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1314 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1MKK · Disulfide deficient mutant of vascular endothelial growth factor A (C61A and C104A) · the same entry in another collection · chain A against A, TM-score 1.00
- P15692 · AlphaFold monomer V2.0 prediction for vascular endothelial growth factor a (P15692) · a predicted model of the same protein · chain B against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15692
- Elsewhere: RCSB PDB 1MKK · PDBe 1MKK · UniProt P15692
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