Crystal structure of gef domain of dennd 1A in complex with rab GTPase RAB35-GDP bound state.

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains C, D
• SO4 · Sulfate ion · ion · 9 copies · chains A, C, B, D
• EDO · 1,2-ethanediol · additive · 8 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6EKK · Crystal structure of GEF domain of DENND 1A in complex with Rab GTPase Rab35-GDP bound… · the same entry in another collection · chain D against D, TM-score 1.00
• Q8TEH3 · AlphaFold monomer V2.0 prediction for denn domain-containing protein 1A (Q8TEH3) · a predicted model of the same protein · chain A against A, TM-score 0.99
• Q15286 · AlphaFold monomer V2.0 prediction for RAS-related protein rab-35 (Q15286) · a predicted model of the same protein · chain C against A, TM-score 0.85

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8TEH3
• Every structure of UniProt Q15286
• Elsewhere: RCSB PDB 6EKK · PDBe 6EKK · UniProt Q8TEH3 · UniProt Q15286