MolNFT v1 · #147612 · protein

DYRK1A in complex with hg-8-60-1

6EIJ: “DYRK1A in complex with hg-8-60-1”. X-ray diffraction, 1 ligand (B5Z). MolNFT v1 #147612 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6EIJ
Type: protein
Length: 1,359 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q13627
Ligands: B5Z

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	342	—	Q13627
B	—	protein	340	—	Q13627
C	—	protein	338	—	Q13627
D	—	protein	339	—	Q13627

Ligands and binding sites

B5Z · ~{N}-[5-[3-(2-morpholin-4-ylethylcarbamoylamino) phenyl]-[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide · ligand · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6EIJ · DYRK1A in complex with HG-8-60-1 · the same entry in another collection · chain D against D, TM-score 1.00
Q13627 · AlphaFold monomer V2.0 prediction for dual specificity tyrosine… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13627
Elsewhere: RCSB PDB 6EIJ · PDBe 6EIJ · UniProt Q13627

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