MolNFT v1 · #147610 · protein
The crystal structure of 14-3-3 epsilon in complex with the phosphorylated nelfe peptide
6EIH · 14-3-3 protein epsilon: “The crystal structure of 14-3-3 epsilon in complex with the phosphorylated nelfe peptide”. X-ray diffraction, 3 pockets (best druggability 0.59). MolNFT v1 #147610 on GenesisL1: 3D structure, binding sites…
- PDB
- 6EIH
- Type
- protein
- Length
- 234 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein epsilon; Ser-ile-sep-arg
- UniProt
- P62258
- Pockets
- 3 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 82% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 14-3-3 protein epsilon | protein | 230 | 83% helix, 0% strand | P62258 |
| P | Ser-ile-sep-arg | protein | 4 | 0% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 248 | 0.59 | 0.79 | 30 | empty |
| 2 | 79 | 0.46 | 0.81 | 19 | empty |
| 3 | 72 | 0.38 | 0.78 | 17 | empty |
Interfaces
1 interface between chains.
- A–P · 361 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 6EIH · The crystal structure of 14-3-3 epsilon in complex with the phosphorylated NELFE peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P62258 · AlphaFold monomer V2.0 prediction for 14-3-3 protein epsilon (P62258) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62258
- Elsewhere: RCSB PDB 6EIH · PDBe 6EIH · UniProt P62258
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.