UniProt P62258
14-3-3 protein epsilon (P62258)
14-3-3 protein epsilon (UniProt P62258): 13 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P62258
- Protein
- 14-3-3 protein epsilon
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 21 · 5 records with a druggable one
Structures
14 records of P62258 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2BR9 | 14-3-3 Protein Epsilon (Human) Complexed to Peptide | x-ray diffraction | A | — | — |
| 2BR9 | 14-3-3 protein epsilon (human) complexed to peptide | x-ray diffraction | A | — | — |
| 3UAL | Crystal Structure of 14-3-3 epsilon with Mlf1 peptide | x-ray diffraction | A | — | — |
| 3UAL | Crystal structure of 14-3-3 epsilon with MLF1 peptide | x-ray diffraction | A | — | — |
| 3UBW | Complex of 14-3-3 isoform epsilon, a Mlf1 phosphopeptide and a small fragment hit from a FBDD screen | x-ray diffraction | A | — | — |
| 3UBW | Complex of 14-3-3 isoform epsilon, a MLF1 phosphopeptide and a small fragment hit from a fbdd screen | x-ray diffraction | A | — | — |
| 6EIH | The crystal structure of 14-3-3 epsilon in complex with the phosphorylated NELFE peptide | x-ray diffraction | A | — | 3 (best 0.59) |
| 6EIH | The crystal structure of 14-3-3 epsilon in complex with the phosphorylated nelfe peptide | x-ray diffraction | A | — | — |
| 7C8E | Crystal structure of 14-3-3 epsilon with 9J10 peptide | x-ray diffraction | A, B | — | — |
| 8DGM | 14-3-3 epsilon bound to phosphorylated PEAK1 (pT1165) peptide | x-ray diffraction | A | — | 3 (best 0.60) |
| 8DGN | 14-3-3 epsilon bound to phosphorylated PEAK2 (pS826) peptide | x-ray diffraction | A | — | 4 (best 0.60) |
| 8DP5 | Structure of the PEAK3/14-3-3 complex | electron microscopy | D | — | 4 (best 0.84) |
| 8Q1S | Pathogenic mutations of human phosphorylation sites affect protein-protein interactions | x-ray diffraction | A, B | BR, NA | 7 (best 0.70) |
| P62258 | AlphaFold monomer V2.0 prediction for 14-3-3 protein epsilon (P62258) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8Q1S chain B against the predicted model P62258: TM-score 0.99, RMSD 0.68 Å
- 6EIH chain A against the predicted model P62258: TM-score 0.98, RMSD 0.73 Å
- 6EIH chain A against the predicted model P62258: TM-score 0.98, RMSD 0.73 Å
- 3UBW chain A against the predicted model P62258: TM-score 0.98, RMSD 0.76 Å
- 3UBW chain A against the predicted model P62258: TM-score 0.98, RMSD 0.76 Å
- 8Q1S chain A against the predicted model P62258: TM-score 0.98, RMSD 0.74 Å
- 3UAL chain A against the predicted model P62258: TM-score 0.98, RMSD 0.77 Å
- 3UAL chain A against the predicted model P62258: TM-score 0.98, RMSD 0.77 Å
- 2BR9 chain A against the predicted model P62258: TM-score 0.98, RMSD 0.82 Å
- 2BR9 chain A against the predicted model P62258: TM-score 0.98, RMSD 0.82 Å
Elsewhere
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