MolNFT v1 · #147392 · protein
The voltage-activated KV1.2-2.1 paddle chimera channel in lipid nanodiscs, transmembrane domain of subunit alpha
6EBM · Potassium voltage-gated channel subfamily a member 2…: “The voltage-activated KV1.2-2.1 paddle chimera channel in lipid nanodiscs, transmembrane domain of subunit…”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT…
- PDB
- 6EBM
- Type
- protein
- Length
- 1,192 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium voltage-gated channel subfamily a member 2, potassium voltage-gated channel…
- UniProt
- P63142, Q63099
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 64% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, D, F, H | Potassium voltage-gated channel subfamily a member 2, potassium voltage-gated channel subfamily B member 2 chimera | protein | 298 | 64% helix, 0% strand | P63142, Q63099 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 846 | 0.82 | 0.84 | 44 | empty |
| 2 | 525 | 0.69 | 0.79 | 73 | empty |
| 3 | 566 | 0.69 | 0.78 | 68 | empty |
| 4 | 244 | 0.66 | 0.83 | 37 | empty |
| 5 | 249 | 0.65 | 0.82 | 39 | empty |
Interfaces
6 interfaces between chains.
- B–H · 1701 Ų buried · 8 hydrogen bonds · protein-protein
- F–H · 1700 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 1699 Ų buried · 7 hydrogen bonds · protein-protein
- D–F · 1690 Ų buried · 7 hydrogen bonds · protein-protein
- D–H · 33 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6EBM · The voltage-activated Kv1.2-2.1 paddle chimera channel in lipid nanodiscs, transmembrane… · the same entry in another collection · chain B against B, TM-score 1.00
- P63142 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily a member… · a predicted model of the same protein · chain B against A, TM-score 0.94
- Q63099 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily B member… · a predicted model of the same protein · chain B against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63142
- Every structure of UniProt Q63099
- Elsewhere: RCSB PDB 6EBM · PDBe 6EBM · UniProt P63142 · UniProt Q63099
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