MolNFT v1 · #147360 · protein

Crystal structure of human respiratory syncytial virus fusion glycoprotein inhibitor escape variant T400A stabilized in the prefusion state

6EAJ · Fusion glycoprotein F0: “Crystal structure of human respiratory syncytial virus fusion glycoprotein inhibitor escape variant T400A…”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.44). MolNFT v1 #147360 on…

PDB: 6EAJ
Type: protein
Length: 443 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fusion glycoprotein F0
UniProt: W8RJF9
Ligands: SO4
Pockets: 2 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
F	Fusion glycoprotein F0	protein	443	30% helix, 34% strand	W8RJF9

Ligands and binding sites

SO4 · Sulfate ion · ion · 11 copies · chains F
NHE · 2-[N-cyclohexylamino]ethane sulfonic acid · additive · chains F
TAR · D(-)-tartaric acid · additive · chains F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	165	0.44	0.75	25	empty
2	60	0.27	0.74	14	empty

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

6EAJ · Crystal structure of human respiratory syncytial virus fusion glycoprotein inhibitor… · the same entry in another collection · chain F against F, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt W8RJF9
Elsewhere: RCSB PDB 6EAJ · PDBe 6EAJ · UniProt W8RJF9

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