MolNFT v1 · #147354 · protein
Crystal structure of human respiratory syncytial virus fusion glycoprotein inhibitor escape variant F140I stabilized in the prefusion state
6EAD · Fusion glycoprotein F0: “Crystal structure of human respiratory syncytial virus fusion glycoprotein inhibitor escape variant F140I…”. X-ray diffraction, 2 ligands (NAG, SO4), 3 pockets (best druggability 0.38). MolNFT v1 #147354 on…
- PDB
- 6EAD
- Type
- protein
- Length
- 450 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion glycoprotein F0
- UniProt
- W8RJF9
- Ligands
- NAG, SO4
- Pockets
- 3 · best druggability 0.38
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F | Fusion glycoprotein F0 | protein | 450 | 29% helix, 33% strand | W8RJF9 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains F
- SO4 · Sulfate ion · ion · 2 copies · chains F
- NHE · 2-[N-cyclohexylamino]ethane sulfonic acid · additive · chains F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 117 | 0.38 | 0.74 | 22 | empty |
| 2 | 67 | 0.34 | 0.76 | 14 | empty |
| 3 | 58 | 0.33 | 0.77 | 14 | empty |
Modifications
Observed in the structure: 7 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 6EAD · Crystal structure of human respiratory syncytial virus fusion glycoprotein inhibitor… · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt W8RJF9
- Elsewhere: RCSB PDB 6EAD · PDBe 6EAD · UniProt W8RJF9
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