MolNFT v1 · #147177 · protein
Chimeric structure of saccharomyces cerevisiae GCN4 leucine zipper fused to staphylococcus aureus agrc cytoplasmic histidine kinase module (dataset anisotropically truncated by staraniso)
6E52 · Staphylococcus aureus agrc histidine kinase module fused to…: “Chimeric structure of saccharomyces cerevisiae GCN4 leucine zipper fused to staphylococcus aureus agrc…”. X-ray diffraction, 5 pockets (best druggability 0.68). MolNFT…
- PDB
- 6E52
- Type
- protein
- Length
- 472 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Staphylococcus aureus agrc histidine kinase module fused to saccharomyces cerevisiae GCN4…
- UniProt
- P03069, A0A0E1AMS6
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Staphylococcus aureus agrc histidine kinase module fused to saccharomyces cerevisiae GCN4 leucine zipper | protein | 243 | 59% helix, 16% strand | P03069, A0A0E1AMS6 |
| B | Staphylococcus aureus agrc histidine kinase module fused to saccharomyces cerevisiae GCN4 leucine zipper | protein | 229 | 59% helix, 17% strand | P03069, A0A0E1AMS6 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 556 | 0.68 | 0.78 | 46 | empty |
| 2 | 454 | 0.61 | 0.75 | 39 | empty |
| 3 | 103 | 0.45 | 0.79 | 19 | empty |
| 4 | 156 | 0.41 | 0.74 | 19 | empty |
| 5 | 77 | 0.31 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 3295 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 6E52 · Chimeric structure of Saccharomyces cerevisiae GCN4 leucine zipper fused to… · the same entry in another collection · chain A against A, TM-score 1.00
- P03069 · AlphaFold monomer V2.0 prediction for general control transcription factor GCN4 (P03069) · a predicted model of the same protein · chain A against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03069
- Every structure of UniProt A0A0E1AMS6
- Elsewhere: RCSB PDB 6E52 · PDBe 6E52 · UniProt P03069 · UniProt A0A0E1AMS6
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