Research workbench
Chimeric structure of saccharomyces cerevisiae GCN4 leucine zipper fused to staphylococcus aureus agrc cytoplasmic histidine kinase module (dataset anisotropically truncated by staraniso)
Analyse Chimeric structure of saccharomyces cerevisiae GCN4 leucine zipper fused to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6E52
- Type
- protein
- Length
- 472 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Staphylococcus aureus agrc histidine kinase module fused to saccharomyces cerevisiae GCN4…
- UniProt
- P03069, A0A0E1AMS6
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Staphylococcus aureus agrc histidine kinase module fused to saccharomyces cerevisiae GCN4 leucine zipper | protein | 243 | 59% helix, 16% strand | P03069, A0A0E1AMS6 |
| B | Staphylococcus aureus agrc histidine kinase module fused to saccharomyces cerevisiae GCN4 leucine zipper | protein | 229 | 59% helix, 17% strand | P03069, A0A0E1AMS6 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 556 | 0.68 | 0.78 | 46 | empty |
| 2 | 454 | 0.61 | 0.75 | 39 | empty |
| 3 | 103 | 0.45 | 0.79 | 19 | empty |
| 4 | 156 | 0.41 | 0.74 | 19 | empty |
| 5 | 77 | 0.31 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 3295 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 6E52 · Chimeric structure of Saccharomyces cerevisiae GCN4 leucine zipper fused to… · the same entry in another collection · chain A against A, TM-score 1.00
- P03069 · AlphaFold monomer V2.0 prediction for general control transcription factor GCN4 (P03069) · a predicted model of the same protein · chain A against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03069
- Every structure of UniProt A0A0E1AMS6
- Elsewhere: RCSB PDB 6E52 · PDBe 6E52 · UniProt P03069 · UniProt A0A0E1AMS6
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