MolNFT v1 · #147095 · protein

The CARD9 card domain-swapped dimer

6E28 · Caspase recruitment domain-containing protein 9: “The CARD9 card domain-swapped dimer”. X-ray diffraction, 1 pocket (best druggability 0.37). MolNFT v1 #147095 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6E28
Type: protein
Length: 186 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Caspase recruitment domain-containing protein 9
UniProt: Q9H257
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 2 distinct chains · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Caspase recruitment domain-containing protein 9	protein	96	73% helix, 0% strand	Q9H257
D	Caspase recruitment domain-containing protein 9	protein	90	78% helix, 0% strand	Q9H257

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	91	0.37	0.75	20	empty

Interfaces

1 interface between chains.

C–D · 3456 Å² buried · 30 hydrogen bonds · protein-protein

Compared structures

6E28 · The CARD9 CARD domain-swapped dimer · the same entry in another collection · chain C against C, TM-score 1.00
Q9H257 · AlphaFold monomer V2.0 prediction for caspase recruitment domain- containing protein 9… · a predicted model of the same protein · chain D against A, TM-score 0.48

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H257
Elsewhere: RCSB PDB 6E28 · PDBe 6E28 · UniProt Q9H257

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