MolNFT v1 · #147094 · protein
The CARD9 card domain-swapped dimer with a zinc ion bound to one of the two zinc binding sites
6E27 · Caspase recruitment domain-containing protein 9: “The CARD9 card domain-swapped dimer with a zinc ion bound to one of the two zinc binding sites”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.40). MolNFT v1…
- PDB
- 6E27
- Type
- protein
- Length
- 184 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Caspase recruitment domain-containing protein 9
- UniProt
- Q9H257
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Caspase recruitment domain-containing protein 9 | protein | 95 | 74% helix, 0% strand | Q9H257 |
| D | Caspase recruitment domain-containing protein 9 | protein | 89 | 80% helix, 0% strand | Q9H257 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 105 | 0.40 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- C–D · 3526 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 6E27 · The CARD9 CARD domain-swapped dimer with a zinc ion bound to one of the two zinc binding… · the same entry in another collection · chain C against C, TM-score 1.00
- Q9H257 · AlphaFold monomer V2.0 prediction for caspase recruitment domain- containing protein 9… · a predicted model of the same protein · chain D against A, TM-score 0.48
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H257
- Elsewhere: RCSB PDB 6E27 · PDBe 6E27 · UniProt Q9H257
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