MolNFT v1 · #147060 · protein
Handover mechanism of the growing pilus by the bacterial outer membrane usher fimd
6E14 · Type 1 fimbrin D-mannose specific adhesin: “Handover mechanism of the growing pilus by the bacterial outer membrane usher fimd”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #147060 on GenesisL1: 3D structure…
- PDB
- 6E14
- Type
- protein
- Length
- 1,586 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Type 1 fimbrin D-mannose specific adhesin; Fimbrial biogenesis outer membrane usher…
- UniProt
- P08191, A0A0F3W955, P08189, P08190, P31697
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 5 distinct chains · 2% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Type 1 fimbrin D-mannose specific adhesin | protein | 279 | 0% helix, 39% strand | P08191 |
| D | Fimbrial biogenesis outer membrane usher protein | protein | 805 | 2% helix, 46% strand | A0A0F3W955 |
| F | Protein fimf | protein | 154 | 2% helix, 32% strand | P08189 |
| G | Protein fimg | protein | 143 | 0% helix, 38% strand | P08190 |
| C | Chaperone protein fimc | protein | 205 | 1% helix, 40% strand | P31697 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 981 | 0.86 | 0.87 | 117 | empty |
| 2 | 982 | 0.84 | 0.86 | 116 | empty |
| 3 | 466 | 0.77 | 0.86 | 62 | empty |
| 4 | 559 | 0.75 | 0.82 | 64 | empty |
| 5 | 542 | 0.75 | 0.82 | 68 | empty |
Interfaces
8 interfaces between chains.
- D–G · 1978 Ų buried · 15 hydrogen bonds · protein-protein
- F–C · 1532 Ų buried · 22 hydrogen bonds · protein-protein
- D–C · 1494 Ų buried · 5 hydrogen bonds · protein-protein
- H–G · 1199 Ų buried · 19 hydrogen bonds · protein-protein
- F–G · 1180 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 6E14 · Handover mechanism of the growing pilus by the bacterial outer membrane usher FimD · the same entry in another collection · chain C against C, TM-score 1.00
- P08191 · AlphaFold monomer V2.0 prediction for type 1 fimbrin D-mannose specific adhesin (P08191) · a predicted model of the same protein · chain H against A, TM-score 0.94
- P31697 · AlphaFold monomer V2.0 prediction for chaperone protein fimc (P31697) · a predicted model of the same protein · chain C against A, TM-score 0.94
- P08190 · AlphaFold monomer V2.0 prediction for protein fimg (P08190) · a predicted model of the same protein · chain G against A, TM-score 0.88
- P08189 · AlphaFold monomer V2.0 prediction for protein fimf (P08189) · a predicted model of the same protein · chain F against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08191
- Every structure of UniProt A0A0F3W955
- Every structure of UniProt P08189
- Every structure of UniProt P08190
- Every structure of UniProt P31697
- Elsewhere: RCSB PDB 6E14 · PDBe 6E14 · UniProt P08191 · UniProt A0A0F3W955 · UniProt P08189 · UniProt P08190 · UniProt P31697
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