MolNFT v1 · #14699 · protein
Crystal structure of the pH-beach domain of human neurobeachin
1MI1: “Crystal structure of the pH-beach domain of human neurobeachin”. X-ray diffraction, 9 pockets (best druggability 0.74). MolNFT v1 #14699 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1MI1
- Type
- protein
- Length
- 814 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neurobeachin
- UniProt
- Q8NFP9
- Pockets
- 9 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Neurobeachin | protein | 414 | 35% helix, 14% strand | Q8NFP9 |
| B | Neurobeachin | protein | 400 | 40% helix, 15% strand | Q8NFP9 |
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 552 | 0.74 | 0.82 | 63 | empty |
| 2 | 580 | 0.72 | 0.80 | 53 | empty |
| 3 | 329 | 0.61 | 0.78 | 43 | empty |
| 4 | 371 | 0.58 | 0.75 | 44 | empty |
| 5 | 322 | 0.56 | 0.75 | 43 | empty |
Interfaces
1 interface between chains.
- A–B · 1013 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 modified (engineered).
Compared structures
- 1MI1 · Crystal Structure of the PH-BEACH Domain of Human Neurobeachin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NFP9
- Elsewhere: RCSB PDB 1MI1 · PDBe 1MI1 · UniProt Q8NFP9
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