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Crystal structure of the pH-beach domain of human neurobeachin

Analyse Crystal structure of the pH-beach domain of human neurobeachin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1MI1
Type: protein
Length: 814 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neurobeachin
UniProt: Q8NFP9
Pockets: 9 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neurobeachin	protein	414	35% helix, 14% strand	Q8NFP9
B	Neurobeachin	protein	400	40% helix, 15% strand	Q8NFP9

Pockets

9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	552	0.74	0.82	63	empty
2	580	0.72	0.80	53	empty
3	329	0.61	0.78	43	empty
4	371	0.58	0.75	44	empty
5	322	0.56	0.75	43	empty

Interfaces

1 interface between chains.

A–B · 1013 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 modified (engineered).

Compared structures

1MI1 · Crystal Structure of the PH-BEACH Domain of Human Neurobeachin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8NFP9
Elsewhere: RCSB PDB 1MI1 · PDBe 1MI1 · UniProt Q8NFP9

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