MolNFT v1 · #146818 · protein
Mitogen-activated protein kinase 6
6DTL: “Mitogen-activated protein kinase 6”. X-ray diffraction, 7 pockets (best druggability 0.73). MolNFT v1 #146818 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6DTL
- Type
- protein
- Length
- 713 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 6
- EC
- 2.7.11.24
- UniProt
- Q39026
- Pockets
- 7 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 6 (EC 2.7.11.24) | protein | 356 | 37% helix, 16% strand | Q39026 |
| B | Mitogen-activated protein kinase 6 (EC 2.7.11.24) | protein | 357 | 39% helix, 15% strand | Q39026 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1086 | 0.73 | 0.76 | 91 | empty |
| 2 | 521 | 0.69 | 0.79 | 58 | empty |
| 3 | 52 | 0.40 | 0.82 | 14 | empty |
| 4 | 60 | 0.37 | 0.79 | 15 | empty |
| 5 | 60 | 0.33 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 322 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q39026
- Elsewhere: RCSB PDB 6DTL · PDBe 6DTL · UniProt Q39026
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