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Mitogen-activated protein kinase 6

Analyse Mitogen-activated protein kinase 6 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6DTL
Type: protein
Length: 713 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitogen-activated protein kinase 6
EC: 2.7.11.24
UniProt: Q39026
Pockets: 7 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitogen-activated protein kinase 6 (EC 2.7.11.24)	protein	356	37% helix, 16% strand	Q39026
B	Mitogen-activated protein kinase 6 (EC 2.7.11.24)	protein	357	39% helix, 15% strand	Q39026

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1086	0.73	0.76	91	empty
2	521	0.69	0.79	58	empty
3	52	0.40	0.82	14	empty
4	60	0.37	0.79	15	empty
5	60	0.33	0.76	13	empty

Interfaces

1 interface between chains.

A–B · 322 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6DTL · Mitogen-activated protein kinase 6 · the same entry in another collection · chain B against B, TM-score 1.00
Q39026 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 6 (Q39026) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q39026
Elsewhere: RCSB PDB 6DTL · PDBe 6DTL · UniProt Q39026

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