MolNFT v1 · #146775 · protein
Beta-galactosidase
6DRV: “Beta-galactosidase”. Electron microscopy, 20 pockets (best druggability 0.82). MolNFT v1 #146775 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6DRV
- Type
- protein
- Length
- 4,096 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-galactosidase
- EC
- 3.2.1.23
- UniProt
- P00722
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 15% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Beta-galactosidase (EC 3.2.1.23) | protein | 1024 | 15% helix, 41% strand | P00722 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 991 | 0.82 | 0.83 | 112 | empty |
| 2 | 563 | 0.81 | 0.87 | 84 | empty |
| 3 | 961 | 0.79 | 0.81 | 111 | empty |
| 4 | 510 | 0.79 | 0.86 | 65 | empty |
| 5 | 858 | 0.78 | 0.82 | 97 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2349 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 2345 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 1934 Ų buried · 24 hydrogen bonds · protein-protein
- B–D · 1932 Ų buried · 24 hydrogen bonds · protein-protein
- B–C · 78 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00722
- Elsewhere: RCSB PDB 6DRV · PDBe 6DRV · UniProt P00722
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