MolNFT v1 · #146732 · protein
Linked KDM5A jmj domain bound to the covalent inhibitor N69 I.E. [2- ((3-ACRYLAMIDOPHENYL)(2-(piperidin-1-YL)ETHOXY)METHYL)THIENO[3,2- B]PYRIDINE-7-carboxylic acid]
6DQ9: “Linked KDM5A jmj domain bound to the covalent inhibitor N69 I.E. [2…”. X-ray diffraction, 2 ligands (H74, MN). MolNFT v1 #146732 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6DQ9
- Type
- protein
- Length
- 299 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P29375
- Ligands
- H74, MN
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 299 | — | P29375 |
Ligands and binding sites
- H74 · 2-{(R)-[3-(acryloylamino)phenyl][2-(piperidin-1-yl) ethoxy]methyl}thieno[3,2-b]pyridine-7-carboxylic acid · ligand · chains A
- MN · Manganese (II) ion · metal · chains A
- DMS · Dimethyl sulfoxide · additive · 2 copies · chains A
- EDO · 1,2-ethanediol · additive · 2 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6DQ9 · Linked KDM5A JMJ Domain Bound to the Covalent Inhibitor N69 i.e.… · the same entry in another collection · chain A against A, TM-score 1.00
- P29375 · AlphaFold monomer V2.0 prediction for lysine-specific demethylase 5A (P29375) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29375
- Elsewhere: RCSB PDB 6DQ9 · PDBe 6DQ9 · UniProt P29375
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