MolNFT v1 · #146569 · protein

Endo-fucoidan hydrolase MFFCNA4 from glycoside hydrolase family 107

6DLH · Alpha-1,4-endofucoidanase: “Endo-fucoidan hydrolase MFFCNA4 from glycoside hydrolase family 107”. X-ray diffraction, 2 ligands (CA, NA), 5 pockets (best druggability 0.62). MolNFT v1 #146569 on GenesisL1: 3D structure, binding sites…

PDB: 6DLH
Type: protein
Length: 704 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-1,4-endofucoidanase
UniProt: Q08I46
Ligands: CA, NA
Pockets: 5 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 19% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alpha-1,4-endofucoidanase	protein	704	19% helix, 29% strand	Q08I46

Ligands and binding sites

CA · Calcium ion · metal · 5 copies · chains A
NA · Sodium ion · metal · chains A
EDO · 1,2-ethanediol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	563	0.62	0.74	65	CA
2	438	0.59	0.75	50	empty
3	190	0.52	0.78	35	EDO
4	148	0.43	0.76	19	empty
5	61	0.34	0.77	14	empty

Compared structures

6DLH · Endo-fucoidan hydrolase MfFcnA4 from glycoside hydrolase family 107 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q08I46
Elsewhere: RCSB PDB 6DLH · PDBe 6DLH · UniProt Q08I46

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