MolNFT v1 · #146417 · protein

Selective PI3K beta inhibitor bound to PI3K delta

6DGT: “Selective PI3K beta inhibitor bound to PI3K delta”. X-ray diffraction, 1 ligand (GFJ). MolNFT v1 #146417 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6DGT
Type: protein
Length: 777 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O35904
Ligands: GFJ

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	777	—	O35904

Ligands and binding sites

GFJ · 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6DGT · Selective PI3K beta inhibitor bound to PI3K delta · the same entry in another collection · chain A against A, TM-score 1.00
O35904 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O35904
Elsewhere: RCSB PDB 6DGT · PDBe 6DGT · UniProt O35904

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