MolNFT v1 · #300423 · protein
AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (O35904)
O35904: “AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta…”. 14 pockets (best druggability 0.84). MolNFT v1 #300423 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O35904
- Type
- protein
- Length
- 1,043 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xB29B34A78d7321f16aB2459F55fd866D8B305953
- Molecule
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- UniProt
- O35904
- Pockets
- 14 · best druggability 0.84
Structure
1 distinct chain · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | protein | 1043 | 43% helix, 18% strand | O35904 |
Pockets
14 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1015 | 0.84 | 0.85 | 94 | empty |
| 2 | 802 | 0.79 | 0.83 | 78 | empty |
| 3 | 715 | 0.73 | 0.79 | 62 | empty |
| 4 | 569 | 0.70 | 0.79 | 51 | empty |
| 5 | 515 | 0.66 | 0.77 | 46 | empty |
Compared structures
- 6ZAD · PI3K delta in complex with methoxymethyloxathiatetraazatetracyclodocosahexaenedione · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6ZAD · PI3K Delta in complex with methoxymethyloxathiatetraazatetracyclodocosahexaenedione · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 7POT · PI3 kinase delta in complex with N-[5-(3,6-dihydro-2H-pyran-4-yl)-2-methoxypyridin-3-yl]be… · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 7POT · PI3 kinase delta in complex with N-[5-(3,6-dihydro-2H-pyran-4-yl)-2… · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6Q73 · PI3K delta in complex with N[2CHLORO5(3,6DIHYDRO2HPYRAN4YL) PYRIDIN3YL]METHANESULFONAMIDE · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6Q73 · PI3K delta in complex with N[2chloro5(3,6dihydro2Hpyran4yl)pyridin3yl]methanesulfonamide · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6TNR · PI3K delta in complex with N[5(7{2[4(2HYDROXYPROPAN2YL)PIPERIDIN1… · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6TNR · PI3K delta in complex with N[5(7{2[4(2hydroxypropan2yl)piperidin1… · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6ZAC · PI3K delta in complex with [(dimethylamino) METHYLDIHYDROBENZOXAZIN2METHOXYPYRIDINYL]METHA… · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6ZAC · PI3K Delta in complex with [(dimethylamino)methyldihydrobenzoxazin2methoxypyridinyl]methan… · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6HI1 · PI3 kinase delta in complex with 3[6(MORPHOLIN4YL)PYRIDIN2YL]PHENOL · an experimental structure of the same protein · chain A against A, TM-score 0.81
- 6HI1 · PI3 Kinase Delta in complex with 3[6(morpholin4yl)pyridin2yl]phenol · an experimental structure of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O35904
- Elsewhere: UniProt O35904 · AlphaFold DB O35904
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