MolNFT v1 · #146363 · protein + DNA
Kaiso (ZBTB33) zinc finger DNA binding domain in complex with the specific kaiso binding sequence (kbs), pH 6.5
6DF8 · Transcriptional regulator kaiso: “Kaiso (ZBTB33) zinc finger DNA binding domain in complex with the specific kaiso binding sequence (kbs), pH…”. X-ray diffraction, 2 ligands (ZN, CL), 5 pockets (best druggability 0.75). MolNFT v1…
- PDB
- 6DF8
- Type
- protein + DNA
- Length
- 154 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator kaiso; DNA (5'- D(*TP*GP*CP*TP*TP*CP*CP*TP*GP*CP*CP*AP*AP*TP*AP*…
- UniProt
- Q86T24
- Ligands
- ZN, CL
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 31% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional regulator kaiso | protein | 118 | 31% helix, 22% strand | Q86T24 |
| D | DNA (5'- D(*TP*GP*CP*TP*TP*CP*CP*TP*GP*CP*CP*AP*AP*TP*AP*AP*CP*G)-3') | dna | 18 | — | — |
| E | DNA (5'- D(*CP*GP*TP*TP*AP*TP*TP*GP*GP*CP*AP*GP*GP*AP*AP*GP*CP*A)-3') | dna | 18 | — | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 185 | 0.75 | 0.91 | 27 | empty |
| 2 | 90 | 0.54 | 0.85 | 15 | empty |
| 3 | 105 | 0.38 | 0.75 | 14 | empty |
| 4 | 80 | 0.35 | 0.76 | 17 | empty |
| 5 | 70 | 0.32 | 0.76 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–D · 819 Ų buried · 14 hydrogen bonds · protein-nucleic
- D–E · 810 Ų buried · 81 hydrogen bonds · nucleic-nucleic
- A–E · 790 Ų buried · 18 hydrogen bonds · protein-nucleic
Compared structures
- 6DF8 · Kaiso (ZBTB33) zinc finger DNA binding domain in complex with the specific Kaiso binding… · the same entry in another collection · chain A against A, TM-score 1.00
- Q86T24 · AlphaFold monomer V2.0 prediction for transcriptional regulator kaiso (Q86T24) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86T24
- Elsewhere: RCSB PDB 6DF8 · PDBe 6DF8 · UniProt Q86T24
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