MolNFT v1 · #146350 · protein
Human caspase-6 E35K
6DEV: “Human caspase-6 E35K”. X-ray diffraction, 17 pockets (best druggability 0.84). MolNFT v1 #146350 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6DEV
- Type
- protein
- Length
- 898 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Caspase-6
- EC
- 3.4.22.59
- UniProt
- P55212
- Pockets
- 17 · best druggability 0.84
Structure
x-ray diffraction · 4 distinct chains · 37% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Caspase-6 (EC 3.4.22.59) | protein | 225 | 36% helix, 17% strand | P55212 |
| B | Caspase-6 (EC 3.4.22.59) | protein | 225 | 37% helix, 17% strand | P55212 |
| C | Caspase-6 (EC 3.4.22.59) | protein | 225 | 39% helix, 17% strand | P55212 |
| D | Caspase-6 (EC 3.4.22.59) | protein | 223 | 37% helix, 16% strand | P55212 |
Pockets
17 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 877 | 0.84 | 0.86 | 82 | empty |
| 2 | 487 | 0.66 | 0.77 | 48 | empty |
| 3 | 164 | 0.65 | 0.86 | 26 | empty |
| 4 | 139 | 0.56 | 0.83 | 26 | empty |
| 5 | 63 | 0.55 | 0.88 | 18 | empty |
Interfaces
6 interfaces between chains.
- C–D · 1530 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1444 Ų buried · 13 hydrogen bonds · protein-protein
- A–D · 346 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 309 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 279 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55212
- Elsewhere: RCSB PDB 6DEV · PDBe 6DEV · UniProt P55212
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