Research workbench

Human caspase-6 E35K

Analyse Human caspase-6 E35K in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6DEV
Type: protein
Length: 898 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Caspase-6
EC: 3.4.22.59
UniProt: P55212
Pockets: 17 · best druggability 0.84

Structure

x-ray diffraction · 4 distinct chains · 37% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Caspase-6 (EC 3.4.22.59)	protein	225	36% helix, 17% strand	P55212
B	Caspase-6 (EC 3.4.22.59)	protein	225	37% helix, 17% strand	P55212
C	Caspase-6 (EC 3.4.22.59)	protein	225	39% helix, 17% strand	P55212
D	Caspase-6 (EC 3.4.22.59)	protein	223	37% helix, 16% strand	P55212

Pockets

17 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	877	0.84	0.86	82	empty
2	487	0.66	0.77	48	empty
3	164	0.65	0.86	26	empty
4	139	0.56	0.83	26	empty
5	63	0.55	0.88	18	empty

Interfaces

6 interfaces between chains.

C–D · 1530 Å² buried · 14 hydrogen bonds · protein-protein
A–B · 1444 Å² buried · 13 hydrogen bonds · protein-protein
A–D · 346 Å² buried · 1 hydrogen bond · protein-protein
B–D · 309 Å² buried · 1 hydrogen bond · protein-protein
A–C · 279 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6DEV · Human caspase-6 E35K · the same entry in another collection · chain D against D, TM-score 1.00
P55212 · AlphaFold monomer V2.0 prediction for caspase-6 (P55212) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P55212
Elsewhere: RCSB PDB 6DEV · PDBe 6DEV · UniProt P55212

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