MolNFT v1 · #146339 · protein
Crystal structure of candida albicans acetohydroxyacid synthase catalytic subunit
6DEK · Acetolactate synthase: “Crystal structure of candida albicans acetohydroxyacid synthase catalytic subunit”. X-ray diffraction, 4 ligands (FAD, TPP, K), 4 pockets (best druggability 0.80). MolNFT v1 #146339 on GenesisL1: 3D…
- PDB
- 6DEK
- Type
- protein
- Length
- 595 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acetolactate synthase
- EC
- 2.2.1.6
- UniProt
- A0A1D8PJF9
- Ligands
- FAD, TPP, K, MG
- Pockets
- 4 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acetolactate synthase (EC 2.2.1.6) | protein | 595 | 41% helix, 16% strand | A0A1D8PJF9 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · chains A
- TPP · Thiamine diphosphate · ligand · chains A
- K · Potassium ion · metal · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 613 | 0.80 | 0.85 | 92 | FAD, TPP |
| 2 | 127 | 0.60 | 0.85 | 23 | empty |
| 3 | 106 | 0.46 | 0.79 | 16 | empty |
| 4 | 123 | 0.40 | 0.75 | 17 | K |
Compared structures
- 6DEK · Crystal structure of Candida albicans acetohydroxyacid synthase catalytic subunit · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1D8PJF9
- Elsewhere: RCSB PDB 6DEK · PDBe 6DEK · UniProt A0A1D8PJF9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.