MolNFT v1 · #14629 · protein

Macrophage migration inhibitory factor Y95F mutant

1MFF: “Macrophage migration inhibitory factor Y95F mutant”. X-ray diffraction, 2 pockets (best druggability 0.79). MolNFT v1 #14629 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1MFF
Type: protein
Length: 342 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Macrophage migration inhibitory factor
UniProt: P34884
Pockets: 2 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Macrophage migration inhibitory factor	protein	114	39% helix, 31% strand	P34884

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	552	0.79	0.85	66	empty
2	65	0.52	0.85	13	empty

Interfaces

3 interfaces between chains.

B–C · 1146 Å² buried · 20 hydrogen bonds · protein-protein
A–B · 1126 Å² buried · 20 hydrogen bonds · protein-protein
A–C · 1102 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

1MFF · Macrophage migration inhibitory factor Y95F mutant · the same entry in another collection · chain A against A, TM-score 1.00
P34884 · AlphaFold monomer V2.0 prediction for macrophage migration inhibitory factor (P34884) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P34884
Elsewhere: RCSB PDB 1MFF · PDBe 1MFF · UniProt P34884

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